Abstract
A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity's (up to >100x) for ER-beta over ER-alpha are reported.
MeSH terms
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Cell Line, Tumor
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Crystallography, X-Ray
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Estrogen Receptor alpha / metabolism
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Estrogen Receptor beta / chemistry
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Estrogen Receptor beta / metabolism*
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Heterocyclic Compounds / chemical synthesis
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Heterocyclic Compounds / pharmacokinetics*
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Humans
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Indicators and Reagents
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Kinetics
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Ligands
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Selective Estrogen Receptor Modulators / chemistry
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Structure-Activity Relationship
Substances
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Estrogen Receptor alpha
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Estrogen Receptor beta
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Heterocyclic Compounds
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Indicators and Reagents
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Ligands
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Selective Estrogen Receptor Modulators